News
We are very happy to see the results of our latest research online at BioRXiv: https://www.biorxiv.org/content/10.1101/2025.11.21.689792v1
We could show that LNPs are able to transfect a variety of retinal cell types - including neurons! By previous ILM peeling, transfection efficacy can be improved!
On September 4th, 2025, we had the honour to host for the 5th meeting of the eye research groups from Gießen and Marburg, marking another exciting opportunity to share knowledge and advance our collaborative work in ophthalmology. After what we hope was a restful summer break, we—along with the groups led by Diana Pauly (Marburg), Knut Stieger (Gießen), Heidrun Deissler (Gießen), and Markus Preising (Gießen)—were excited to reconnect, exchange ideas, and dive back into our research.
The meeting was filled with insightful presentations from both PhD students and PIs, reflecting the range of experimental approaches we're exploring in our eye research efforts in Marburg and Gießen.
It’s always inspiring to see the hard work and creativity within our community. Some of the fascinating topics we discussed included:
- Nanoparticles for mRNA Delivery in Ocular Therapy
- Gene Editing in the ABCA4 Gene
- The Effect of AAV-Expressed Opsonins on Gene Expression in RD1 Mice
- Characterization of a Rod/Cone Degeneration Mouse Model for Gene Therapy
- Impact of Hyperoxia on the Vascular Network in iNOS Deficient and Wild-Type Mice
- Claudin-1, Proteasome Inhibitors, and Endothelial Cell Barrier Function
- C3 and Its Role in RPE Cells
Overall, the meeting was a vibrant exchange of ideas and a perfect reflection of how collaborative work can push the boundaries of experimental eye research. The breadth of topics we covered highlighted just how dynamic our field is and reminded us of the importance of interdisciplinary collaboration.
Some biophysics from our lab! With the LIAISON consortium (https://www.kvs-liaison.eu/) we could show that Silent KV channels, previously thought to only heteromerize with KV2 (KCNB) family members can indeed also form complexes, and likely heteotetramerize with KV7 (KCNQ) channels, substantially broadening the their biophysical diversity. The full paper is available at CMLS.
We are very happy to see the results of our latest research online at BioRXiv: https://www.biorxiv.org/content/10.1101/2024.07.22.604613v1. The visual code that can be achieved by targeting ON bipolar cells with optogenetic therapy is much richer as when targeting retinal ganglion cells! A great collaborative work led by our colleagues in Manchester!
Joint photo of groups from the Neurophysiology Department! Great colleagues gathering in front of the historic ruins of the Hospital of Elisabeth of Thuringia, right in the Institute's garden!
